element.onclick = function(event){
  // Do anything.
};

element.onclick = function(event){
  // Other code here.
  doSomethingElse();
};

element.onclick = function(event){
  // Other code here.
  doSomethingElse();
  setPosition(event.clientX, event.clientY);
};

element.onclick = function(event){
  doMission1();
  doMission2(event.clientX, event.clientY);
  doMission3();
  // ...
  doMissionXX();
};

element.onclick = function(event){
  amplify.publish( "aya:clicked", {
    x: event.clientX,
    y: event.clientY
  });
};

amplify.subscribe( "aya:clicked", doMission1);
// ...
amplify.subscribe( "aya:clicked", doMission2);
// ...

(function( global, undefined ) {

var slice = [].slice,
  subscriptions = {};

var amplify = global.amplify = {
  publish: function( topic ) {
    // ...
  },

  subscribe: function( topic, context, callback, priority ) {
    // ...
  },

  unsubscribe: function( topic, context, callback ) {
    // ...
  }
};

}( this ) );

publish: function( topic ) {
  // [1]
  if ( typeof topic !== "string" ) {
    throw new Error( "You must provide a valid topic to publish." );
  }
  // [2]
  var args = slice.call( arguments, 1 ),
    topicSubscriptions,
    subscription,
    length,
    i = 0,
    ret;

  if ( !subscriptions[ topic ] ) {
    return true;
  }
  // [3]
  topicSubscriptions = subscriptions[ topic ].slice();
  for ( length = topicSubscriptions.length; i < length; i++ ) {
    subscription = topicSubscriptions[ i ];
    ret = subscription.callback.apply( subscription.context, args );
    if ( ret === false ) {
      break;
    }
  }
  return ret !== false;
},

subscribe: function( topic, context, callback, priority ) {
    if ( typeof topic !== "string" ) {
      throw new Error( "You must provide a valid topic to create a subscription." );
    }
    // [1]
    if ( arguments.length === 3 && typeof callback === "number" ) {
      priority = callback;
      callback = context;
      context = null;
    }
    if ( arguments.length === 2 ) {
      callback = context;
      context = null;
    }
    priority = priority || 10;
    // [2]
    var topicIndex = 0,
      topics = topic.split( /\s/ ),
      topicLength = topics.length,
      added;
    for ( ; topicIndex < topicLength; topicIndex++ ) {
      topic = topics[ topicIndex ];
      added = false;
      if ( !subscriptions[ topic ] ) {
        subscriptions[ topic ] = [];
      }
      // [3]
      var i = subscriptions[ topic ].length - 1,
        subscriptionInfo = {
          callback: callback,
          context: context,
          priority: priority
        };
      // [4]
      for ( ; i >= 0; i-- ) {
        if ( subscriptions[ topic ][ i ].priority <= priority ) {
          subscriptions[ topic ].splice( i + 1, 0, subscriptionInfo );
          added = true;
          break;
        }
      }
      // [5]
      if ( !added ) {
        subscriptions[ topic ].unshift( subscriptionInfo );
      }
    }

    return callback;
  },

amplify.subscribe( string topic, function callback )
amplify.subscribe( string topic, object context, function callback )
amplify.subscribe( string topic, function callback, number priority )
amplify.subscribe(
  string topic, object context, function callback, number priority )

unsubscribe: function( topic, context, callback ) {
  if ( typeof topic !== "string" ) {
    throw new Error( "You must provide a valid topic to remove a subscription." );
  }

  if ( arguments.length === 2 ) {
    callback = context;
    context = null;
  }

  if ( !subscriptions[ topic ] ) {
    return;
  }

  var length = subscriptions[ topic ].length,
    i = 0;

  for ( ; i < length; i++ ) {
    if ( subscriptions[ topic ][ i ].callback === callback ) {
      if ( !context || subscriptions[ topic ][ i ].context === context ) {
        subscriptions[ topic ].splice( i, 1 );
        
        // Adjust counter and length for removed item
        i--;
        length--;
      }
    }
  }
}

amplify.subscribe( "dataexample", function( data ) {
  alert( data.foo ); // bar
});

//...

amplify.publish( "dataexample", { foo: "bar" } );