方法如下： 声明一个事件：  Num_DiscountAmount.MouseWheel +=new MouseEventHandler(Num_DiscountAmount_MouseWheel); 编写一个事件 private void  Num_DiscountAmount_MouseWheel(object sender, MouseEventArgs e) { HandledMouseEventArgs h = e as HandledMouseEventArgs; if (h != null) { h.Handled = true; } } 还有 第三方控件　DevExpress.XtraEditors.SpinEdit ,如何禁用鼠标中间键　？ 方法如下： 声明事件： (SpinEdit1.Controls[0] as DevExpress.XtraEditors.TextBoxMaskBox).MouseWheel += new MouseEventHandler(Frm_MouseWheel); 编写事件： void Frm_MouseWheel(object sender, MouseEventArgs e) { if (e.Delta != 0) DevExpress.Utils.DXMouseEventArgs.GetMouseArgs(e).Handled = true; }