android:configChanges="screenSize|smallestScreenSize|screenLayout|orientation"

 @Override
 public void onMultiWindowModeChanged(boolean isInMultiWindowMode) {
 super.onMultiWindowModeChanged(isInMultiWindowMode);
 //在此处根据isInMultiWindowMode来适配多窗口UI
 }

Activity().isInMultiWindowMode()

<activity
  android:name="com.android.multiwindowplayground.activities.MinimumSizeActivity"
  android:launchMode="singleInstance"
  android:taskAffinity="">
  <layout
  android:defaultHeight="500dp"
  android:defaultWidth="750dp"
  android:gravity="top|end"
  android:minWidth="500dp"
  android:minHeight="500dp" />
 </activity>

<LinearLayout android:id="@+id/layout"
 xmlns:android="http://schemas.android.com/apk/res/android"
 android:layout_width="match_parent"
 android:layout_height="match_parent"
 android:background="@color/white"
 android:orientation="vertical">
 <ScrollView
 android:id="@+id/scrollview"
 android:layout_width="match_parent"
 android:layout_height="0dp"
 android:layout_gravity="top"
 android:layout_weight="0.75">
 <TextView
  android:id="@+id/description"
  android:layout_width="wrap_content"
  android:layout_height="wrap_content"
  android:layout_gravity="center"
  android:paddingBottom="@dimen/activity_vertical_margin"
  android:paddingLeft="@dimen/activity_horizontal_margin"
  android:paddingRight="@dimen/activity_horizontal_margin"
  android:paddingTop="@dimen/activity_vertical_margin"
  android:textColor="@color/white" />
 </ScrollView>
 <include
 layout="@layout/logging"
 android:layout_width="match_parent"
 android:layout_height="0dp"
 android:layout_gravity="bottom"
 android:layout_weight="0.25" />
</LinearLayout>

@Override
 public void onConfigurationChanged(Configuration newConfig) {
 super.onConfigurationChanged(newConfig);
 int screenWidthDp=newConfig.screenWidthDp;
 int screenHeightDp=newConfig.screenHeightDp;
 //根据宽高动态改变布局
 }